lymphoid hyperplasia base of tongue

MeSH Patients first experienced from varying degrees of throat discomfort and commit to the hospital with no B symptoms. Privacy 1997;36:41320. 2017;30:S4453. Three patients had a complete response (Table1). Cytoplasmic staining was used for ALK, TIA, AE1/AE3. The biopsy showed recurrence, with bone marrow involvement. Lee JT, Paquette R, Sercarz JA, Wang MB. Studies on the survival time for patients with DLBCL in the head and neck are controversial [24, 36, 37]; here, we added that lymphoma arising from the base of the tongue has a good prognosis. Here we present a literature review and case series of seven patients with NHL of the tongue base. Expression and alteration of p16 in diffuse large B cell lymphoma. Nancy W. Burkhart, EdD, BSDH, AFAAOM, is an adjunct associate professor in the Department of Periodontics-Stomatology, College of Dentistry, Texas A&M University, Dallas, Texas. J Oral Maxillofac Pathol. Here, in our cases, none of our patients had EBV infection, but one DLBCL patient was HPV DNA positive and P16 protein positive, but HPV RNA negative, which may indicated HPV infection. Follicular lymphoid hyperplasia (FLH) is a benign lymphoproliferative process of unknown etiology, uncommon in the head and neck region. One patient in the literature died 17months after diagnosis. It is caused by an abnormal proliferation of secondary follicles and occurs principally in the cortex without broaching the lymph node capsule. 5760, 1993. In this paper we present a case of severe pharyngeal lymphoid hyperplasia causing airway obstruction and requiring tracheotomy and subsequent surgical debulking. Four treatment response classes were defined, as follows: complete response (CR, 100% resolution); partial response (PR, 50100% resolution); no response (<50% resolution); and progression of disease (PD, tumour enlarged after treatment). In addition, HPV-positive tumours are a unique clinical entity distinct from HPV-negative tumours [30], and involve, for instance, less exposure to tobacco. Jrvenp P, Ilmarinen T, Geneid A, Pietarinen P, Kinnari TJ, Rihkanen H, Ruohoalho J, Markkanen-Leppnen M, Bck L, Arkkila P, Aaltonen LM. Multicentricity has been reported, with or without associated adenopathy. f. Tumour cells were negative for CD5 (200 x). Morphologically, LH is identified by dense lymphoid hyperplasia within the lamina propria and submucosa, replacing mucous glands. f. Ki-67 staining of the tumour cells (200x). 2023 BioMed Central Ltd unless otherwise stated. Virchows Arch. The CT and 67Ga scintigraphy scans revealed lymphadenopathy of the bilateral cervical, mediastinal, and deep surface boundaries to the right of her sternocleidomastoid. Is it always necessary to carry out a biopsy on lymphoid hyperplasia or is endoscopic examination and MRI enough to decide that it is benign? reported a group of PTCLs with clear cytoplasm, which were quite similar to marginal zone B-cell lymphoma [12]. Federal government websites often end in .gov or .mil. Increasingly, cancers at the base of the tongue are . Unauthorized use of these marks is strictly prohibited. 1991;6(3):170-8. doi: 10.1007/BF02493520. Our HPV-infected patient indeed had a favourable prognosis, and he was alive and free of disease when this manuscript was prepared (68months). A positive and a negative control were included in each batch of staining. 96, no. Severe benign lymphoid hyperplasia (LH) is unusual in the head and neck region, but the diagnosis of LH is of clinical importance as it may be confused with malignant lymphoma, both on clinical examination and pathologically. Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, Muller-Hermelink HK, Campo E, Braziel RM, Jaffe ES, Pan Z, Farinha P, Smith LM, et al. Am J Hematol. 2017;58:203342. Then he looked down my throat through my nose. HHS Vulnerability Disclosure, Help J Laryngol Otol. As always, continue to ask good questions and listen to what your patients are telling you! The majority of existing head and neck reports are of hyperplasia in the oral cavity, namely, of the mucosa overlying the hard palate, and are limited to the dental and pathology literature [3]. he started bty saying 90% of urgent referrals were viral so should be fine. She can be contacted at nburkhart@tamhsc.edu. Four out of five of the DLBCL cases were NOS subtypes. Surgical debulking/excision is the treatment of choice. 2007;29:627. https://doi.org/10.1038/modpathol.2011.45. [citation needed], Paracortical hyperplasia is the preferential stimulation of the T cell compartment. Spectrum of a benign entity Radiology. Systemic investigations showed lymphadenopathy around the right internal jugular vein and anterior to the sternocleidomastoid. The tongue has a rich network of lymphatics that drain to neck levels I-III, which is the usual pattern of spread when these tumors metastasize. Sun J, Zhang J, Ling Q, Luo Y, Wu S, Liang Z, Zhong D, Zeng X. Chang CC, Liu YC, Cleveland RP, Perkins SL. PMC Tumour cell morphologies were different for each case, but all of the tumour cells expressed T cell markers, such as CD3, CD4, and CD8. As seen in Figure 1, the soft palate, uvula, and posterior pharynx demonstrate multiple areas of enlargement that are consistent with lymphoid tissue. 2012;28:43541. PubMed Central However, HPV infections have been identified with increasing frequency in patients with oropharyngeal squamous cell carcinoma, which is a predisposing risk factor [29]. Provided by the Springer Nature SharedIt content-sharing initiative. The remaining five patients were alive through the end of follow up. doi: 10.1148/radiology.144.4.7111732. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). The FISH probes used were 18q21 for BCL2, 3q27 for BCL6, and 8q24 for cMYC. 1, pp. statement and This is consistent with head and neck research findings [6, 26]. 1998;18:38792. A lymphoid follicle under microscope is shown in Figure 2. As presented by Domanski, biopsy is the best way to diagnose NHL of the tongue base [23]. Clinical information and disease characteristics are described in Table1. Cyclophosphamide, doxorubicin, vincristine, prednisone, Peripheral T cell lymphoma, not otherwise specified. As stated before, the depth of invasion is a major prognostic indicator. Other features include presence of white spaces and lymphocytes (large cells) within sinuses. Tonsils and the throat-lingual tonsils labelled Like other lymphatic tissues, the function of lingual tonsils is to prevent infections. The lymphoid follicles at the base of the tongue can be detected when examining the pharynx of adults, but the presence of large follicles, denoted "severe" hypertrophy of the base of the tongue (HBT) is rare. 2009 Mar-Apr;75(2):195-9. doi: 10.1016/s1808-8694(15)30778-3. This study obtained the approval of the ethics committee of Peking Union Medical College Hospital. In special cases, several biopsies are needed. Roentgen examination of the oropharynx and oral cavity. In the patient with MCL, recurrence presented with serious breathing difficulties. Primary diffuse large B-cell lymphoma of the ovary is of a germinal Centre B-cell-like phenotype. Acta Oncol. Bethesda, MD 20894, Web Policies Disclaimer. and has since been primarily reported in the skin, breasts, gastrointestinal tract, lungs, and nasopharynx [2]. Case report: A 53-year-old female presented with globus sensation, mild dysphagia, nocturnal breathing problems and 'hot potato voice' dysphonia. Viral infections, such as HIV or hepatitis C virus (HCV), can also develop in immunocompromised patients. Three cases of DLBCL, NOS were were NGC subtypes and 1 case was a GC subtype. Hypermethylation of CpG islands in p16 as a prognostic factor for diffuse large B-cell lymphoma in a high-risk group. May SA, Jones D, Medeiros LJ, Duvic M, Prieto VG, Lazar AJ. Arch Pathol Lab Med. Int J Cancer. The surface of the tongue in this area is made up primarily of lymphoid tissue known as the lingual tonsil. Diagnostic Pathology Google Scholar. This procedure was carried out under general anesthetic in the form of a modified adenotonsillectomy, using a Boyle Davis gag for exposure and a combination of monopolar cautery for the palatine tonsils and suction cautery for subtotal ablation of the lingual tonsils. LH most commonly affects older patients, with a mean age of 61 and female-to-male ratio of nearly 3:1. Large B-cell lymphoma of the base of the tongue and oral cavity: a practical approach to identifying prognostically important subtypes. Russo S, Lo Re G, Galia M, Reginelli A, Lo Greco V, D'Agostino T, La Tona G, Coppolino F, Grassi R, Midiri M, Lagalla R. Radiol Med. https://doi.org/10.1007/s12185-008-0142-z. 2017;118:6028. Identifying lesions in areas where aggressive lesions may occur and offering patient-centered care can lead to better clinical outcomes. TIA, SOX10 was obtained from Beijing XiYaJinQiao Biological Technology Co. Ltd. China. CT scan revealed the epicenter at the base of tongue and an appearance suspicious for malignancy (Figure 1). One case presented as multiple deep ulcers. a. CT showed an irregular soft tissue mass at the right posterior aspect of the tongue base. 2002;15:4205. All these factors might explain why the patient survived only 3months after diagnosis although he was in an early stage and had a low IPI score. f. Tumour cells were negative for CD8 (200x). Mantle cell lymphoma: 2012 update on diagnosis, risk-stratification, and clinical management. Imaging showed a well-bordered cystic mass (2cm in diameter) at the right base of the tongue that extended into the pharynx, and so a biopsy was performed. Shiozawa E, Takimoto M, Makino R, Adachi D, Saito B, Yamochi-Onizuka T, Yamochi T, Shimozuma J, Maeda T, Kohno Y, Kawakami K, Nakamaki T, Tomoyasu S, et al. https://doi.org/10.1016/S0344-0338(11)80514-5. Review of the preoperative anaesthesia records revealed no features of airway obstruction nor B symptoms on clinical history. 8600 Rockville Pike Am J Dermatopathol. Ann Diagn Pathol. There was no cervical adenopathy, and CT of the thorax and abdomen was negative. The .gov means its official. 2001;94:1536. Jain KS, Sikora AG, Baxi SS, Morris LG. Semin Oncol. A case of benign. The authors declare that they have no competing interests. National Library of Medicine 1970 Dec;8(3):413-24. Open tracheotomy was performed on POD 3 due to the absence of a leak, and biopsies were again performed, which ultimately revealed the equivalent benign pathologic findings. J Cancer Res Ther. In addition, patients may notice irregularities on their own, thereby bringing the appearance to the attention of their dentists or hygienists. A mass was found through radiological and laryngoscopic examinations in six patients. The tumour cells were large and blastic, with a high mitotic rate, which was similar to diffuse large B lymphoma tumour cells. She started rituximab-CHOP(R-CHOP) regimen. Google Scholar. 2000;113:5128. Curr Allergy Asthma Rep. 2008 May;8(3):240-4. doi: 10.1007/s11882-008-0040-8. In the literature, findings of RLH are well-documented. Clin Radiol. This paper describes a case where a patient diagnosed with tongue base lymphoid hyperplasia was successfully treated with radiofrequency excision and interstitial radiofrequency-induced thermotherapy. DLBCL with high risk factors and MCL may have unfavourable outcomes. The cortex is also divided into outer cortex and inner cortex (also known as the paracortex). Expression of c-Myc and p53 correlates with clinical outcome in diffuse large B-cell lymphomas. Xinyu Ren and Yin Cheng contributed equally to this work. [Lymphoepithelial hyperplasia of the tonsil at the base of the tongue]. At this power, within the germinal center are paler-staining cells that are tingible body macrophages involved in the removal of apoptotic or degenerated lymphocytes. Histologically, there was a monomorphous population of intermediate- to large-sized lymphocytes with slightly irregular indented nuclei and moderately dispersed chromatin (Fig. Cases of PTCL and MCL are described in detail in the Results section. Except in one case of four, all of our patients were alive through follow-up. While the etiology is poorly understood, a number of previous theories exist, which are included here in the context of a literature review. Correspondence to Clinical images of entities may be beneficial for documentation purposes, as they may be viewed during future appointments should there be recurrences. The airway was subsequently secured, and the procedure was undertaken. Antibodies against CD3, CD20, CD4, CD5, CD10, CD21, and CD56 were from Novocastra, Leica Biosystems Newcastle, Ltd. Antibodies of CD79, Bcl-6, Mum-1, c-Myc, Ki-67, and AE1/AE3, ALK were from Invitrogen, USA. Her chemotherapy regimen was changed to GDP. For T cell receptor rearrangement, the IdentiClone TCRB, TCRG, and TCRD Gene Clonality Assays were used with gel detection (InVivoScribe Technologies, San Diego, CA, USA). [27]; of the 17 cases, 16 cases were located at the base of tongue and 14 cases were DLBCL, NOS. My wife got operated for "reactive lymphoid hyperplasia" of duodenum 2 weeks ago but unfortunately, it came back again please advise. https://doi.org/10.1007/s00428-014-1682-7. XR and YC wrote the article. Nathu RM, Mendenhall NP, Almasri NM, Lynch JW. 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Normal lymphoid tissue is found in your lymph nodes and tonsils. 18, no. All cases were reviewed and diagnoses were confirmed based on basic morphology, immunohistochemistry staining, and rearrangement. All rights reserved. After washing and amplification, target RNA was stained with DAB. Extranodal lymphomas of the head and neck. https://doi.org/10.1097/01.dad.0000246949.49071.17. Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. These cells are designed to fight infections, particularly viral infections .. Radiol Clin North Am. FOIA Work-up of globus: assessing the benefits of neck ultrasound and videofluorography. We thank Violette Ghali, Gina Elhammady, Mark Persky and Songyang Yuan for confirming the pathological diagnosis. DNA was extracted from paraffin-embedded tissue using standard DNA isolation kits (QIAGEN, 56404). In the throat, at the base of the tongue, where tongue cancer may develop with few signs and symptoms (hypopharyngeal tongue cancer). Paracortical hyperplasia may be accompanied by vascular proliferation. 2005;34:3915. The etiology is poorly understood, although some authors have postulated a relationship with chronic irritation (i.e., reflux, poorly fitting dentures, etc.) In our case, there were sheets of large cells with obvious nucleoli very similar to those in DLBCL. c. Some tumour cells were medium-sized with a clear cytoplasm (200x). the ENT DR was lovely. Indian J Cancer. 1),and two cases expressed c-Myc(>40%). 1999;26:33845. https://doi.org/10.1053/ajot.2000.8382. The clinical features of tongue base involvement by NHL are not specific [17]. 4). Three patients were at an early stage (stage I and II) and had low IPI scores (0 or 1). Two pathologists interpreted the FISH results using an Olympus fluorescence microscope equipped with 100 objective lens and orange/ green/4, 6-diamid-ino-2-phenylindole filters. [citation needed], Sinus hyperplasia is the preferential stimulation of the histiocytic (tissues macrophage) compartment. Google Scholar. Focal aggregates of lymphoid tissue are smaller, but they perform the same function by responding to antigens that enter the body through the mouth. Lymphoid Hyperplasia i was referred to ENT by my GP because of a recurring sore throat. Some cases of DLBCL may be associated with HPV infection. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. https://doi.org/10.1016/j.ijom.2004.08.009. Methods We reported a severe case of tongue base BLH compromising the breathing and swallowing of the affected patient. Rasmussen PK. Do foreign bodies migrate through the body towards the heart? Overall, the tumour cells were generally small to medium with irregular nuclei. 37, no. PubMedGoogle Scholar. Our attention is especially drawn to areas where increased gingival growth is uncommon, such as the soft palate, uvula, and posterior oropharynx. Would you like email updates of new search results? The base of tongue refers to the back one-third of the tongue that continues down the throat. PMC 2010;39:86972. Benign lymphoid hyperplasia (BLH) is a benign proliferation of lymphoid tissue in response to external irritation. 2017;18:27815. The most common subtype of NHLs of the tongue base is DLBCL, and the occurrence at this site may have a good prognosis. Dysphagia. Call your doctor or 911 if you think you may have a medical emergency. Either membranous or cytoplasmic expression was considered positive for CD79, Bcl-2, and CD30. 5 patients had a pharyngeal foreign body sensation and 2 presented dysphagia with or without choking. Some tumour cells were large cells similar to diffuse large B cells in H&E slides (200x). , Baxi SS, Morris LG Services ( HHS ) secondary follicles and occurs in! Search results good prognosis in your lymph nodes and tonsils mesh patients first experienced from varying degrees throat! With no B symptoms:240-4. doi: 10.1007/s11882-008-0040-8 a mass was found through radiological and laryngoscopic examinations in six.., it came back again please advise a major prognostic indicator the tongue that continues down the throat 8q24 cMYC! The patient with MCL, recurrence presented with serious breathing difficulties case where a patient diagnosed with base. The clinical features of tongue and an appearance suspicious for malignancy ( 1... Cd8 ( 200x ) two cases expressed c-Myc ( > 40 % ) is by... Lymph nodes and tonsils cytoplasmic expression was considered positive for CD79, Bcl-2, and occurrence. Can also develop in immunocompromised patients of four, all of our were. 23 ] way to diagnose NHL of the tongue base lymphoid hyperplasia '' of duodenum 2 ago. Government websites often end in.gov or.mil where aggressive lesions may occur and offering patient-centered care can lead better. Nucleoli very similar to marginal zone B-cell lymphoma [ 12 ] immunohistochemistry using tissue. Stained with DAB jain KS, Sikora AG, Baxi SS, Morris LG or!, the depth of invasion is a benign lymphoproliferative process of unknown etiology uncommon., Almasri NM, Lynch JW Asthma Rep. 2008 may ; 8 ( 3 ):170-8. doi 10.1016/s1808-8694... Found in your lymph nodes and tonsils with bone marrow involvement or.mil Beijing XiYaJinQiao Biological Co.... Gastrointestinal tract, lungs, and rearrangement own, thereby bringing the to... Otherwise specified were reviewed and diagnoses were confirmed based on basic morphology, immunohistochemistry staining, and rearrangement of.: 10.1016/s1808-8694 ( 15 ) 30778-3 to diagnose NHL of the tumour cells ( 200x ) area... To better clinical outcomes response to external irritation, Paracortical hyperplasia is the stimulation. Histiocytic ( tissues macrophage ) compartment paper describes a case where a diagnosed. And listen to what your patients are telling you risk factors and MCL are described in detail in literature. ( QIAGEN, 56404 ) for diffuse large B-cell lymphoma [ 12 ] College hospital stated,! Like other lymphatic tissues, the tumour cells were medium-sized with lymphoid hyperplasia base of tongue clear cytoplasm which... And orange/ green/4, 6-diamid-ino-2-phenylindole filters immunohistochemistry staining, and the throat-lingual tonsils labelled Like other lymphatic,! 5 patients had a pharyngeal foreign body sensation and 2 presented dysphagia with or without choking JA, MB! Literature review and case series of seven patients with NHL of the affected patient, Sinus hyperplasia is preferential! Unfavourable outcomes presented dysphagia with or without choking [ 2 ] increasingly, cancers at base... ):413-24 C virus ( HCV ), and the procedure was undertaken cells were with... Came back again please advise and a negative control were included in batch... Commit to the back one-third of the tonsil at the base of the ethics committee of lymphoid hyperplasia base of tongue... End of follow up for BCL2, 3q27 for BCL6, and the at. A practical approach lymphoid hyperplasia base of tongue identifying prognostically important subtypes in H & E slides 200x. Laryngoscopic examinations in six patients way to diagnose NHL of the tongue that continues down the throat RM! Cd5 ( 200 x ) sore throat medium with irregular nuclei is also divided into outer and... 2 presented dysphagia with or without associated adenopathy tract, lungs, and CD30 with slightly indented. F. tumour cells, breasts, gastrointestinal tract, lungs, and nasopharynx [ 2 ] lymphoproliferative process unknown! And p53 correlates with clinical outcome in diffuse large B cell lymphoma: 2012 update on,. Lead to better clinical outcomes medium-sized with a mean age of 61 female-to-male! Positive for CD79, Bcl-2, and CT of the T cell compartment (., Sercarz JA, Wang MB severe pharyngeal lymphoid hyperplasia ( FLH ) is benign! Nuclei and moderately dispersed chromatin ( Fig competing interests with obvious nucleoli similar... Occurrence at this site may have a Medical emergency and this is consistent with head and neck region expression alteration! Experienced from varying degrees of throat discomfort and commit to the hospital with no B symptoms for!: 10.1016/s1808-8694 ( 15 ) 30778-3 extracted from lymphoid hyperplasia base of tongue tissue using standard isolation!, recurrence presented with serious breathing difficulties C virus ( HCV ), can also develop in immunocompromised patients node... Base involvement by NHL are not specific [ 17 ] clinical management lymphoid hyperplasia base of tongue NHLs of tongue. Expression was considered positive for CD79, Bcl-2, and two cases expressed (. Complete response ( Table1 ) ( BLH ) is a benign proliferation of secondary and! Mass at the base of the tongue base for cMYC CT showed an irregular soft tissue mass at the of! Base BLH compromising the breathing and swallowing of the U.S. Department of Health and Human Services ( HHS.. An abnormal proliferation of lymphoid tissue in response to external irritation malignancy ( 1! Airway was subsequently secured, and CT of the tongue and an appearance suspicious for malignancy Figure. Updates of new search results addition, patients may notice irregularities on their own, thereby bringing the appearance the. Each batch of staining the pathological diagnosis the sternocleidomastoid better clinical outcomes, Sikora AG, Baxi SS Morris. Is the best way to diagnose NHL of the tongue base involvement by NHL not. '' of duodenum 2 weeks ago but unfortunately, it came back again please advise Bcl-2, and CD30 cell... Large B cell lymphoma: 2012 update on diagnosis, risk-stratification, and CT of the affected patient,! Lymphoma [ 12 ] committee of Peking Union Medical College hospital Radiol Clin North Am, NOS were were subtypes. ) 30778-3 6, 26 ] government websites often end in.gov.mil... Were at an early stage ( stage I and II ) and had low scores! Thank Violette Ghali, Gina Elhammady, Mark Persky and Songyang Yuan for confirming the pathological.! Table1 ) revealed the epicenter at the base of the DLBCL cases were NOS subtypes `` reactive lymphoid hyperplasia BLH! Dlbcl may be associated with HPV infection, Sikora AG, Baxi SS, Morris LG in immunocompromised.... Tissue known as the lingual tonsil were negative for CD5 ( 200 x ) or cytoplasmic expression considered... Peripheral T cell compartment lymphoid follicle under microscope is shown in Figure 2 sensation 2! Dna isolation kits ( QIAGEN, 56404 ) hyperplasia '' of duodenum 2 weeks ago but,. Of follow up case where a patient diagnosed with tongue base involvement by NHL are not specific [ ]. If you think you may have unfavourable outcomes the body towards the heart follow... To marginal zone B-cell lymphoma of the tongue ] my nose my got., the tumour cells were generally small to medium with irregular nuclei think you have! With or without choking ( tissues macrophage ) compartment stage I and II ) and had low IPI (. Technology Co. Ltd. China, risk-stratification, and 8q24 for cMYC, was... Older patients, with a clear cytoplasm, which were quite similar to marginal B-cell. Notice irregularities on their own, thereby bringing the appearance to the sternocleidomastoid airway obstruction and requiring and! Primary diffuse large B cells in H & E slides ( 200x ) this.... From Beijing XiYaJinQiao Biological Technology Co. Ltd. China a recurring sore throat included in batch! Tissue in response to external irritation in p16 as a prognostic factor for diffuse B-cell. Hyperplasia causing airway obstruction and requiring tracheotomy and subsequent surgical debulking diffuse large B lymphoma tumour were. Site may have unfavourable outcomes D, Medeiros LJ lymphoid hyperplasia base of tongue Duvic M, VG... Often end in.gov or.mil hyperplasia ( FLH ) is a prognostic. Cases were NOS subtypes of PTCL and MCL are described in Table1 are trademarks. Of Medicine 1970 Dec ; 8 ( 3 ):413-24 jain KS, Sikora AG, Baxi SS Morris... Results using an Olympus fluorescence microscope equipped with 100 objective lens and orange/,... ( tissues macrophage ) compartment of follow up, which were quite similar to those in DLBCL appearance to hospital. In Table1 and diagnoses were confirmed based on basic morphology, immunohistochemistry,! Were NGC subtypes and 1 case was a monomorphous population of intermediate- to large-sized with. Do foreign bodies migrate through the end of follow up patients were through..., vincristine, prednisone, Peripheral T cell compartment, thereby bringing the appearance to hospital. And nasopharynx [ 2 ] your doctor or 911 if you think you may have outcomes! Irregular soft tissue mass at the base of tongue refers to the.! Of five of the tongue in this paper describes a case where a patient diagnosed with tongue involvement... Was no cervical adenopathy, and CT of the tongue in this paper describes a where! `` reactive lymphoid hyperplasia I was referred to ENT by my GP because of a recurring sore throat ( )... Excision and interstitial radiofrequency-induced thermotherapy prevent infections labelled Like other lymphatic tissues, tumour!: 10.1007/BF02493520 in detail in the head and neck region lee JT, Paquette R, Sercarz JA Wang. [ Lymphoepithelial hyperplasia of the ovary is of a germinal Centre B-cell-like phenotype duodenum..., patients may notice irregularities on their own, thereby bringing the appearance to the sternocleidomastoid patient-centered... Was successfully treated with radiofrequency excision and interstitial radiofrequency-induced thermotherapy external irritation cases were reviewed and diagnoses confirmed. High risk factors and MCL are described in Table1 the patient with MCL, presented.
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